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Effectiveness of colonoscopy for upper colon questioned by study

02.10.2008 20:01 Health - Source: cbc.ca

The risk of getting cancer in the upper colon is higher than in the lower colon following a negative colonoscopy, a new Ontario study suggests.

The findings raise questions about the effectiveness of a colonoscopy, says Dr. Linda Rabeneck, the lead investigator on the study by the Institute for Clinical Evaluative Sciences.

It shows there is "something different' about cancers in the upper or right colon than the lower colon, she said in a news release Thursday.

The study looked at the records of 110,402 people between the ages of 50 and 80 who had a negative colonoscopy in the province between 1992 and 1997.

In 14 years of followup, the risk of colorectal cancer in the lower colon was reduced when patients were compared with the general population who hadn't had a colonoscopy.

A reduction in the incidence of colon cancer in the upper colon was only seen in about half of the 14 followup years, and mainly in the second seven-year period.

The results suggest that a colonoscopy may not be equally effective for the detection and removal of abnormalities in the lower and upper colon, Rabeneck said.

Although the colonoscopy is not a perfect test, it's the only procedure that can provide a view of the entire colon and allow for the biopsy and removal of abnormalities such as polyps or cancers, Rabeneck said.

More research is needed to determine whether different outcomes result from an issue of colonoscopy quality or differences in tumour biology, she said.

The research was published in the October issue of Clinical Gastroenterology and Hepatology.

With files from the Canadian Press
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